收费全文 | 22985篇 |
免费 | 2285篇 |
国内免费 | 958篇 |
耳鼻咽喉 | 418篇 |
儿科学 | 239篇 |
妇产科学 | 68篇 |
基础医学 | 1342篇 |
口腔科学 | 452篇 |
临床医学 | 6626篇 |
内科学 | 1600篇 |
皮肤病学 | 125篇 |
神经病学 | 3712篇 |
特种医学 | 500篇 |
外国民族医学 | 2篇 |
外科学 | 1314篇 |
综合类 | 1973篇 |
预防医学 | 1603篇 |
眼科学 | 4345篇 |
药学 | 755篇 |
72篇 | |
中国医学 | 818篇 |
肿瘤学 | 264篇 |
2024年 | 46篇 |
2023年 | 549篇 |
2022年 | 750篇 |
2021年 | 1408篇 |
2020年 | 1393篇 |
2019年 | 1215篇 |
2018年 | 1176篇 |
2017年 | 1092篇 |
2016年 | 956篇 |
2015年 | 851篇 |
2014年 | 1531篇 |
2013年 | 2407篇 |
2012年 | 1184篇 |
2011年 | 1124篇 |
2010年 | 974篇 |
2009年 | 854篇 |
2008年 | 925篇 |
2007年 | 975篇 |
2006年 | 817篇 |
2005年 | 676篇 |
2004年 | 582篇 |
2003年 | 568篇 |
2002年 | 480篇 |
2001年 | 425篇 |
2000年 | 334篇 |
1999年 | 256篇 |
1998年 | 227篇 |
1997年 | 180篇 |
1996年 | 134篇 |
1995年 | 186篇 |
1994年 | 133篇 |
1993年 | 140篇 |
1992年 | 142篇 |
1991年 | 121篇 |
1990年 | 106篇 |
1989年 | 104篇 |
1988年 | 96篇 |
1987年 | 89篇 |
1986年 | 100篇 |
1985年 | 174篇 |
1984年 | 143篇 |
1983年 | 121篇 |
1982年 | 125篇 |
1981年 | 106篇 |
1980年 | 95篇 |
1979年 | 39篇 |
1978年 | 34篇 |
1977年 | 26篇 |
1976年 | 20篇 |
1974年 | 11篇 |
Method: Twenty-one participants with MS and 22 healthy adults (HA) underwent a neuropsychological battery including a Selective Reminding PM (SRPM) experimental procedure. Participants were randomly assigned to either: (1) a selective reminding condition in which participants learn (to criterion) eight prospective memory tasks in a Selective Reminding format; or (2) a single trial encoding condition (1T).
Results: A significant interaction was demonstrated, with MS participants receiving greater benefit than HAs from the SR procedure in terms of PM performance. Across diagnostic groups, participants in the SR conditions (vs. 1T conditions) demonstrated significantly better PM performance. Individuals with MS were impaired relative to HAs in the 1T condition, but performance was statistically comparable in the SR condition.
Conclusions: This preliminary study suggests that selective reminding can be used to enhance PM cue detection and retrieval in MS. The extent to which selective reminding of PM is effective in naturalistic settings and for health-related behaviours in MS remains to be determined. 相似文献
Method: 120 male subjects were randomly assigned to (1) MMT plus CRT in two months or (2) MMT plus a control intervention. Subjects were assessed at the beginning, mid-point and post-intervention as well as at 1-, 3- and 6-month follow-up time points.
Results: Analysis with repeated measure ANOVA showed that the CRT group performed significantly better in tests of learning, switching, processing speed, working memory and memory span. Moreover, the CRT group had significantly lower opiate use over the control group during 3-months follow-up. Analysis including only those with a history of methamphetamine use showed that the CRT group had significantly lower amphetamine use. No group differences were observed for treatment retention.
Conclusions: Our findings provide evidence that adding CRT as an adjunct intervention to MMT can improve cognitive performance as well as abstinence from both opiates and stimulants. 相似文献
Methods: Data of 211 eyes of 145 patients with AU associated with AS were reviewed retrospectively.
Results: Mean follow-up time was 6.31 ± 6.33 years. Men were younger than women at AS diagnosis (p = 0.035). The mean number of uveitis flares was highest during the first quarter of the year and lowest during the third quarter (p = 0.017). Immunosuppressive agent use was higher in women than men (p = 0.052). Ocular complications developed in 120 eyes (56.9%), and the complication rate was 0.146/eye year. Males developed cystoid macular edema more frequently than females (p = 0.05). Glaucoma was observed more often in early-onset disease (age at AS onset <45 years) than late-onset disease (p = 0.028).
Conclusions: Visual prognosis of AU in patients with AS was good, although more than half of the eyes developed ocular complications (56.9%). 相似文献
Areas covered: This review was written after detailed search in PubMed, EMBASE, ISI web, SciELO, Scopus, and Cochrane Central Register databases (from 1970 to 2019). It summarized the reported ophthalmologic adverse effects of the currently available AEDs; their risks and possible pathogenic mechanisms. They include ocular motility dysfunctions, retinopathy, maculopathy, glaucoma, myopia, optic neuropathy, and impaired retinal vascular autoregulation. In general, ophthalmo-neuro- or retino-toxic adverse effects of AEDs are classified as type A (dose-dependent), type B (host-dependent or idiosyncratic) or type C which is due to the cumulative effect from long-term use.
Expert opinion: Ocular adverse effects of AEDs are rarely reviewed although some are frequent or may result in permanent blindness. Increasing knowledge of their incidence and improving understanding of their risks and pathogenic mechanisms are crucial for monitoring, prevention, and management of patients’ at risk. 相似文献
Objective: The aims of this study were to assess the preference scores of DM-related complications using both the standard gamble (SG), a choice-based method, and visual analogue scale (VAS), a scaling method. We also aimed to assess several possible factors that might be associated with the preference scores of the complications.
Methods: This is a cross-sectional interview-administered survey, and 213 patients with type 2?DM were interviewed. The respondents’ preference scores of eleven DM-related complications were obtained using VAS and SG techniques. Demographic information, clinical characteristics and risk attitudes were also collected to explore factors that may affect patients’ preference scores.
Results: Nearly one quarter of participants in Taiwan ranked at least one of the complications worse than death. The mean VAS scores ranged from 0.004 (amputation) to 0.47 (nocturnal hypoglycemia) while the mean adjusted SG scores ranged from 0.30 (blindness) to 0.66 (nocturnal hypoglycemia). There were significant differences in all of the complications’ preference scores depending on risk attitudes.
Conclusion: Both the VAS and SG methods were used to elicit the preference scores of DM-related complications, and the preference scores derived could be useful for future cost utility analyses. 相似文献